Dr Fong Lai Yen
Designation: Associate Professor
Faculty / Institute / Centre : M. Kandiah Faculty of Medicine and Health Sciences
Department / Unit: Department of Pre-clinical Sciences
Telephone No: +6 ext
Fax: +603-90197062
Email Address: fongly@utar.edu.my
Google Scholar Profile : https://scholar.google.com/citations?user=23RiD40AAAAJ&hl=en
Orcid ID : https://orcid.org/0000-0001-7912-6746
Qualification: Doctor of Philosophy, Universiti Putra Malaysia ( Physiology )
Bachelor of Science, Universiti Putra Malaysia ( Biomedical Sciences )

   Dr Fong's research interests are vascular biology, drug discovery and natural products. Her group studies vascular protective effects of natural/synthetic compounds and plant extracts, focusing on identification of novel drug leads. Common experimental models available in Dr Fong's lab include primary endothelial cell culture and atherosclerotic animal models (C57/BL6 and apolipoprotein E-knockout mice).

   Previously, Dr Fong's group reported the protective effect of Alternanthera sessilis ethanol extract on TNF-alpha or H2O2-induced induced endothelial activation. LC- and GC-MS analysis showed that the A. sessilis ethanol extract contains 1,3,5-dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one, 3-deoxy-d-mannoic lactone and other compounds. A. sessilis is one of the most commonly consumed salad (ulam) in Malaysia and its traditional medicinal uses include anti-hypertensive and anti-inflammatory effects. Currently, her group is investigating anti-atherosclerotic effect of asiatic acid, a natural compound derived from Centella asiatica, and the role of NADPH oxidases in the pharmacological action of asiatic acid. Besides, the group is also evaluating the activity of a new benzyl amine-substituted xanthone derivative on TNF-alpha-induced vascular dysfunction using in vitro, in vivo and in silico approaches.

    Dr Fong received a number of conference travel awards and published more than 20 journal articles in the past. Her H-index (Scopus) is currently 11.